Tree of Health Alpha GPC 300mg

Availability: In stock
Reference:TOH003
Alpha GPC is "food" for our brain, helping to keep it fit and especially cognitive abilities. Tree of Health contains the highest AAA quality of this raw material.
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21,26 €

Tree of Health  Alpha GPC 300mg

The effects of Alpha GPC have not been approved by the European authorities, we will at least list the effects attributed to the product in traditional approaches to human health. These are not health claims

L-alpha-glycerylphosphorylcholine is a natural choline compound found in the brain. It is also a parasympathomimetic precursor of acetylcholine, which has been investigated for its potential to treat Alzheimer's disease[*1] and other dementias.

Alpha-GPC rapidly delivers choline to the brain across the blood-brain barrier and is a biosynthetic precursor of acetylcholine.It is over-the-counter in most countries. The Food and Drug Administration (FDA) has determined that an intake of no more than 196.2 mg/person/day is considered generally recognized as safe (GRAS)[*2].

Alzheimer disease has a complex etiology composed of nutritional and genetic risk factors and predispositions. Moreover, genetic risk factors for cognitive decline may remain latent pending age-related decline in nutrition, suggesting the potential importance of early nutritional intervention, including preventative approaches. We hypothesized that a combination of multiple nutritional additives may be able to provide neuroprotection. We demonstrate herein that dietary supplementation with a mixture of ALA, ALCAR, GPC, DHA, and PS (alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine)reduced reactive oxygen species in normal mice by 57% and prevented the increase in reactive oxygen species normally observed in mice lacking murine ApoE when maintained on a vitamin-free, iron-enriched, oxidative-challenge diet. We further demonstrate that supplementation with these agents prevented the marked cognitive decline otherwise observed in normal mice maintained on this challenge diet. These findings add to the growing body of research indicating that key dietary supplementation may delay the progression of age-related cognitive decline. [*3]

Recommended dosage

One dose: 2 capsules
Take 2 capsules daily, preferably in the morning with breakfast.

Producer: Fresh2Go s.r.o, Horní 30, Brno 63900

Sources

*1] Parnetti L, Mignini F, Tomassoni D, Traini E, Amenta F (June 2007). "Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation?". Journal of the Neurological Sciences. 257 (1–2): 264–9. doi:10.1016/j.jns.2007.01.043. PMID 17331541. S2CID 34661218.
*2] "Generally Recognized as Safe (GRAS) Determination for the Use of AlphaSize® Alpha-Glycerylphosphoryl Choline"(PDF). United States Food and Drug Administration. 25 January 2012. Archived from the original(PDF) on 24 December 2013. 

LEGAL NOTICE: The efficacy of this substance has not been confirmed by the European Union regulator as sufficiently supported by scientific studies. This product is not intended for the diagnosis, treatment or prevention of any disease.


Warning

This product is not intended for children under 5 years of age and pregnant and lactating women. Side effects:Exceptionally, skin rash or intestinal irritation may occur in sensitive persons. How to store the product: In a shaded, dry place at a temperature below 25°C and out of the reach of children.

Warning:

This product has been marketed as a dietary supplement. It has no approved medicinal properties and is not a medicine. It is not intended as a substitute for a varied diet. Do not exceed recommended dosage. Keep out of reach of children. Minimum shelf life indicated on the packaging. If you are pregnant, breastfeeding, taking prescription medication or under medical supervision, it is advisable to consult a medical practitioner before taking any supplements. Discontinue use and consult a healthcare practitioner if side effects occur. Not suitable for persons under 18 years of age. Keep out of reach of children. Do not use if the seal is broken. Dietary supplements should not be used as a substitute for a balanced diet and healthy lifestyle.

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Tree of Health Alpha GPC 300mg 60vcaps
TOH-003
In stock (76 pc)
21,26 €
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